The Response of Hypo- And Hyperthyroid Immature Female Mice to Gonadotrophin (FSH) †

The level of thyroid function influences the responses of the ovaries to anterior pituitary gonadotrophic preparations and also ovarian function."" w The nature and extent of ovarian responses of hypothyroid rats4"'",M" and mice!" to extrinsic gonadotrophins have been studied extensively. The thyroid level also may influence the threshold of responsiveness or quantitatively limit the response of end organs such as the ovarian response to endogenous gonadotrophinse or the vaginal response to estrogen.7'"0'"' The injection of thyroxin into the ovarian capsule alters the morphology of the ovaries in mice.""' The present experiment was designed to ascertain the influence of hypoand hyperthyroid states in young mice upon the effect of a predominantly follicle-stimulating preparation (FSH) on ovarian function.